Valerophenone

• Category :

  Intermediates/Pharmaceutical intermediates

• Synonyms :

  1-Phenyl-1-pentanone;n-Butyl phenyl ketone;Pentanophenone;

• CAS NO :

  1009-14-9

• EC NO :

  213-767-3

• Molecular Formula :

  C₁₁H₁₄O

• Molecular Weight :

  162.23

• Main Specifications :

  99% min

• InChI :

  InChI=1/C11H14O/c1-2-3-9-11(12)10-7-5-4-6-8-10/h4-8H,2-3,9H2,1H3

• Packing :

  25kg，50kg 200kg

• Product description :

  What is the chemical of Valerophenone ? Appearance: Colorless to pale yellow liquid； Assay:99%min by GC； IR Identity: conform to standard； HNMR： conform to standard； carbon spectrum: conform to standard； Water by K. F.:0.5% max or as per the customer’s request； Loss on drying:0.5% max. or as per the customer’s request； ========================================================================== Acetophenone is a versatile organic compound with primary applications including: Organic synthesis intermediates for synthesizing complex organic molecules such as pharmaceuticals, fragrances, and pesticides; Pharmaceutical intermediates serving as key building blocks in the pharmaceutical industry; Fragrance components used in formulating food flavors and personal care fragrances (e.g., perfumes, cosmetics); Pesticide synthesis as intermediates for insecticides, herbicides, and fungicides; Materials science, where it can act as a monomer or additive for polymer materials (e.g., plastics, rubbers); And as a preservative component in the storage and transportation of aldehyde chemicals. =============================================================================== Pentanone can be prepared via two classical organic synthesis routes, both offering high yields and industrial feasibility: Route 1: Friedel-Crafts Acylation Raw Materials: Benzene + n-Pentanoyl Chloride Catalyst: Anhydrous Aluminum Chloride (AlCl?) Solvent: Dichloromethane (DCM) Reaction Conditions: Temperature: Added dropwise at 0–5 °C, then heated to 40 °C for 2 h reaction Post-treatment: Quenched with hydrochloric acid in an ice bath, liquid-liquid extraction, organic phase concentrated and reduced-pressure distilled Yield: Approximately 87% (142 g from 120.5 g n-pentanoyl chloride) Route 2: Grignard Reaction Raw Materials: Methyl Benzoate + n-Butyl Grignard Reagent (prepared from n-butyl bromide and magnesium) Solvent: Anhydrous Tetrahydrofuran (THF) Reaction Conditions: Grignard reagent addition time: Approximately 30 min Reaction time: Approximately 3 h Post-treatment: Acidic hydrolysis Yield: Approximately 96% (7.8 g from 0.05 mol methyl benzoate) Among the two methods, the Friedel-Crafts method is more suitable for industrial production due to readily available raw materials and stable operation; the Grignard method is suitable for small-scale high-purity preparation. (For reference only)

• Uses :

  Phenylacetone is a versatile organic compound, with main applications including: Organic synthesis intermediate: Used for synthesizing complex organic molecules such as drugs, fragrances, and pesticides.

• Molecular Structure :