3-Chloropropyl methyl ether
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- Category :
Intermediates/Pharmaceutical intermediates
- CAS NO : 36215-07-3
- EC NO : 252-919-3
- Molecular Formula : C4H9ClO
- Main Specifications : 99% min
- Synonyms : propane, 1-chloro-3-methoxy-;3-Methoxypropylchloride;1-Chloro-3-methoxypropane;1-Chloro-3-Methoxy Propane;1-choloro-3-methoxypropane;
Package: 25kg，50kg 200kg
Uses : Mainly used as an etherification reagent
Molecular Structure:
Product description:
What is the chemical of 3-Chloropropyl methyl ether?
Appearance: Colorless to almost clear transparent oily liquid ;
Assay：99%min by GC ;
IR Identity: conform to standard ;
HNMR： conform to standard ;
carbon spectrum: conform to standard ;
Water by K. F.:0.5% max or as per the customer’s request ;
Loss on drying:0.5% max. or as per the customer’s request ;
boiling point: 99.4 ° C (at 760 mmHg);
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Mainly used as an etherification reagent;
It is a precursor of 4-bromo-2- (3-methoxypropoxy) - benzyl ether, a key intermediate in the synthesis of the antihypertensive drug Aliskiren;
Widely used in pharmaceutical intermediates, organic building blocks, and fine chemical synthesis
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synthetic route
According to public information, 3-chloropropyl methyl ether can be synthesized by the following methods:
Add 90 g (1 mol) of 3-methoxy-1-propanol, 5 g of tetramethylammonium chloride, and 200 mL of cyclohexane into a 500 mL four necked bottle;
Maintain the reaction temperature at 65-70 ° C, slowly add 130.9 g (1.1 mol) of thionyl chloride dropwise, and complete the dropwise process in about 3 hours;
After the dropwise addition is complete, continue to keep warm and stir for 2 hours;
After the reaction is complete, cool down to room temperature and wash the organic phase sequentially with 100 mL of water, 50 mL of saturated sodium bicarbonate solution, and 50 mL of water;
Reduce pressure to recover cyclohexane, then distill and collect the 103-106 ° C fraction;
Obtained 3-methoxy-1-chloropropane with a gas chromatography purity of ≥ 99% and a yield of approximately 97.7%
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